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Tummy or duodenal ulcer. If you have a abdomen ulcer or duodenal ulcer, prednisone could make it even worse. Using prednisone using an NSAID (soreness reliever) such as ibuprofen could also boost your chance of acquiring or worsening an ulcer. When you've got a person of such ulcers, talk with your health practitioner about no matter if prednisone